Sepsis: New Insights, New Therapies: Novartis Foundation Symposium 280

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Local innate immune response to mild infection

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Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists. Seller Inventory AAH Publisher: Wiley , Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches.

Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism.

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Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it Describes numerous pharmacological approaches to therapy for early and late sepsis Includes detailed discussion of the various physiological systems implicated in sepsis Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers.

Sepsis, the complex, systemic, clinical syndrome resulting from the innate host inflammatory response to infection, is an increasingly common condition, particularly in an ageing population with multiple comorbidities. Indeed, the annual number of deaths from sepsis rivals those due to myocardial infarction and exceeds the mortality rate of virtually every common cancer, yet the syndrome has received relatively little attention as a modifiable disease process.

Most therapeutic strategies target pro-inflammatory mediators, but these have frequently not improved survival of patients when studied in large, multicentre clinical trials. Greater appreciation of the complex pathophysiology by which sepsis induces multiple organ failure has stimulated research into new therapeutic approaches. Depending on the phase of the septic syndrome, these could even involve stimulation of inflammatory, immune or other systems, so the timing of intervention is important. With advances in supportive care in the intensive care unit, the ability to titrate treatment individually is becoming both a reality and a necessity.

Therapeutic potential of HMGB1-targeting agents in sepsis

This important book brings together contributions from an international group of experts in diverse fields, including adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism, to consider all aspects of sepsis and its treatment. Sadly, despite many therapeutic advances, the mortality of this complex syndrome remains high, posing a major challenge.

This book highlights the complexity of the disorder and signals the directions for future therapeutic endeavour. The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chairman: Mitchell Fink.

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Chadwick Jamie Goode. First published: 26 January Book Series: Novartis Foundation Symposia. About this book Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches.

Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it Describes numerous pharmacological approaches to therapy for early and late sepsis Includes detailed discussion of the various physiological systems implicated in sepsis Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers.

Author Bios The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chairman: Mitchell Fink.